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KMID : 0370219820260030169
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Yakhak Hoeji
1982 Volume.26 No. 3 p.169 ~ p.174
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Studies on the Resistance to Antibiotics in Bacteria Induced Resistance to Macrolide Antibiotics in Bacillus sp.
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Choi Eung-Chil
Kim Byung-Kak
Shim Mi-Ja
Chung Kyeong-Soo
Kim Hye-Rung
Lee Chong-Kil
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Abstract
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Several strains of bacteria having resistance to macrolide antibiotics were isolated. EMR-1, one of them, exhibited the induced resistance to macrolide antibiotics and this microorganism was identified as a bacterium belong to Bacillus species. The subinhibitory concentration of erythromycin or oleandomycin induced strong resistance to both erythromycin and oleandomycin themselves and to other macrolide antibiotics such as leucomycin, spiramycin and josamycin. The effective concentration of inducer, erythromycin was g/ml. The inactivating enzyme of these antibiotics was not produced by EMR-1.
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